V08: Contrast media
ATC V08 contrast media for modelers: contrast media, a pharmacokinetic problem.
Part of V: Various.
Contrast media, a pharmacokinetic problem. Iodinated X-ray media distribute differentially to organs and between normal and abnormal tissue, and are excreted largely unchanged, with a hepatic and biliary route that matters in renal impairment [1]. Iohexol clearance is itself used as a measured GFR [2], and the practical question is the safe interval before the next study [3].
References
[1]
Bourin M, Jolliet P, Ballereau F. An overview of the clinical pharmacokinetics of x-ray contrast media. Clinical Pharmacokinetics 1997;32:180–93. https://doi.org/10.2165/00003088-199732030-00002.
[2]
Mohamed AAA, Bökenkamp A, Cavalier E, Delanaye P, Ebert N, Londen M van. Diverse protocols for measuring glomerular filtration rate using iohexol clearance. Nephrology Dialysis Transplantation 2024;39:1037–9. https://doi.org/10.1093/ndt/gfae006.
[3]
Molen AJ van der, Dekkers IA, Geenen RWF, Bellin M-F, Bertolotto M, Brismar TB, et al. Waiting times between examinations with intravascularly administered contrast media: A review of contrast media pharmacokinetics and updated ESUR contrast media safety committee guidelines. European Radiology 2024;34:2512–23. https://doi.org/10.1007/s00330-023-10085-5.