H05: Calcium homeostasis
Pharmacometric modeling notes for ATC H05, calcium homeostasis.
Part of H: Systemic hormonal preparations, excluding sex hormones and insulins.
Mechanistic extrapolation. QSP is the characteristic modality here: multiscale calcium homeostasis and bone remodeling models predict bone mineral density, and FDA used one reviewing rhPTH(1-84) dosing in hypoparathyroidism [1,2].
References
[1]
Peterson MC, Riggs MM. FDA Advisory Meeting Clinical Pharmacology Review Utilizes a Quantitative Systems Pharmacology (QSP) Model: A Watershed Moment? CPT: Pharmacometrics & Systems Pharmacology 2015;4:e00020. https://doi.org/10.1002/psp4.20.
[2]
Riggs MM, Cremers S. Pharmacometrics and systems pharmacology for metabolic bone diseases. British Journal of Clinical Pharmacology 2019;85:1136–46. https://doi.org/10.1111/bcp.13881.