N03: Antiepileptics

ATC N03 antiepileptics for modelers: counts, not concentrations.
Modified

September 21, 2026

Part of N: Nervous system.

Counts, not concentrations. Daily seizure counts in N03 are overdispersed and depend on the previous day, so negative binomial models with a Markov element beat Poisson [1]. Add-on exposure-response is fitted on seizure rate, not a continuous score [2].

References

[1]
Trocóniz IF, Plan EL, Miller R, Karlsson MO. Modelling overdispersion and Markovian features in count data. Journal of Pharmacokinetics and Pharmacodynamics 2009;36:461–77. https://doi.org/10.1007/s10928-009-9131-y.
[2]
Miller R, Frame B, Corrigan B, Burger P, Bockbrader H, Garofalo E, et al. Exposure-response analysis of pregabalin add-on treatment of patients with refractory partial seizures. Clinical Pharmacology & Therapeutics 2003;73:491–505. https://doi.org/10.1016/S0009-9236(03)00049-3.