B05: Blood substitutes and perfusion solutions

Pharmacometric modeling notes for ATC B05, blood substitutes and perfusion solutions.

Modified

September 21, 2026

Part of B: Blood and blood forming organs.

Easy to overlook. Blood substitutes and perfusion solutions have their own tradition, volume kinetics, fitted to hemoglobin-derived plasma dilution [1,2].

References

[1]

Hahn RG, Zdolsek M, Hasselgren E, Zdolsek J, Björne H. Fluid volume kinetics of 20% albumin. British Journal of Clinical Pharmacology 2019;85:1303–11. https://doi.org/10.1111/bcp.13897.

[2]

Balan C, Boros C, Bubenek-Turconi S-I, Hahn RG. Volume kinetics of gelofusine 4% during vascular surgery. Clinical Pharmacokinetics 2025;64:599–610. https://doi.org/10.1007/s40262-025-01500-9.