N01: Anesthetics

ATC N01 anesthetics for modelers: anesthesia is the hysteresis case.
Modified

September 21, 2026

Part of N: Nervous system.

Anesthesia is the hysteresis case. Processed EEG lags plasma concentration in N01, so the link is an effect site with an equilibration rate constant ke0 [1]. One effect compartment failed to describe the bispectral index across different propofol infusion rates; a two-compartment effect site succeeded [2].

References

[1]
Schnider TW, Minto CF, Shafer SL, Gambus PL, Andresen C, Goodale DB, et al. The influence of age on propofol pharmacodynamics. Anesthesiology 1999;90:1502–16. https://doi.org/10.1097/00000542-199906000-00003.
[2]
Björnsson MA, Norberg Å, Kalman S, Karlsson MO, Simonsson USH. A two-compartment effect site model describes the bispectral index after different rates of propofol infusion. Journal of Pharmacokinetics and Pharmacodynamics 2010;37:243–55. https://doi.org/10.1007/s10928-010-9157-1.