M04: Antigout preparations

ATC M04 antigout preparations for modelers: urate is a turnover problem.
Modified

September 21, 2026

Part of M: Musculo-skeletal system.

Urate is a turnover problem. Serum urate under febuxostat is fitted with an indirect response model [1]; such a model predicted real-world urate with r = 0.68, rising to 0.77 once comorbidities, eGFR and loop diuretics were accounted for [2].

References

[1]
Muraki S, Moriki K, Shigematsu S, Fukae M, Kakara M, Yamashita D, et al. Population pharmacodynamic analysis of uric acid-lowering effects of febuxostat based on electronic medical records in two hospitals. The Journal of Clinical Pharmacology 2018;58:304–13. https://doi.org/10.1002/jcph.1023.
[2]
Hirai T, Itoh T, Kimura T, Echizen H. Evaluation of a pharmacokinetic-pharmacodynamic model for hypouricaemic effects of febuxostat using datasets obtained from real-world patients. British Journal of Clinical Pharmacology 2018;84:2260–9. https://doi.org/10.1111/bcp.13666.