B03: Antianemic preparations
ATC B03 antianemic preparations for modelers: longest delays in the group.
Part of B: Blood and blood forming organs.
Longest delays in the group. Erythropoiesis-stimulating agents act on precursors, so hemoglobin is separated from exposure by maturation and red cell lifespan [1,2]. Lifespan models with an explicit endogenous baseline and feedback are standard [3,4].
References
[1]
Uehlinger DE, Gotch FA, Sheiner LB. A pharmacodynamic model of erythropoietin therapy for uremic anemia. Clinical Pharmacology and Therapeutics 1992;51:76–89. https://doi.org/10.1038/clpt.1992.10.
[2]
Ramakrishnan R, Cheung WK, Wacholtz MC, Minton N, Jusko WJ. Pharmacokinetic and pharmacodynamic modeling of recombinant human erythropoietin after single and multiple doses in healthy volunteers. The Journal of Clinical Pharmacology 2004;44:991–1002. https://doi.org/10.1177/0091270004268411.
[3]
Krzyzanski W, Perez-Ruixo JJ, Vermeulen A. Basic pharmacodynamic models for agents that alter the lifespan distribution of natural cells. Journal of Pharmacokinetics and Pharmacodynamics 2008;35:349–77. https://doi.org/10.1007/s10928-008-9092-6.
[4]
Olsson-Gisleskog P, Jacqmin P, Perez-Ruixo JJ. Population pharmacokinetics meta-analysis of recombinant human erythropoietin in healthy subjects. Clinical Pharmacokinetics 2007;46:159–73. https://doi.org/10.2165/00003088-200746020-00004.