M05: Drugs for treatment of bone diseases
ATC M05 drugs for treatment of bone diseases for modelers: bone markers and density are asynchronous.
Bone markers and density are asynchronous. Antiresorptives move serum CTX long before bone mineral density, and an indirect response model bridges the lag, predicting later density gain from one year of data [1].
References
[1]
Wu J, Wang C, Li GF, Tang ET, Zheng Q. Quantitative prediction of bone mineral density by using bone turnover markers in response to antiresorptive agents in postmenopausal osteoporosis: A model-based meta-analysis. British Journal of Clinical Pharmacology 2021;87:1175–86. https://doi.org/10.1111/bcp.14487.