B05: Blood substitutes and perfusion solutions

Pharmacometric modeling notes for ATC B05, blood substitutes and perfusion solutions.

Modified

September 22, 2026

Easy to overlook. Blood substitutes and perfusion solutions have their own tradition, volume kinetics, fitted to hemoglobin-derived plasma dilution [1,2].

References

[1]

Hahn RG, Zdolsek M, Hasselgren E, Zdolsek J, Björne H. Fluid volume kinetics of 20% albumin. British Journal of Clinical Pharmacology 2019;85:1303–11. https://doi.org/10.1111/bcp.13897.

[2]

Balan C, Boros C, Bubenek-Turconi S-I, Hahn RG. Volume kinetics of gelofusine 4% during vascular surgery. Clinical Pharmacokinetics 2025;64:599–610. https://doi.org/10.1007/s40262-025-01500-9.