M03: Muscle relaxants
ATC M03 muscle relaxants for modelers: relaxants are the effect compartment case.
Relaxants are the effect compartment case. Twitch depression lags plasma concentration, and the hysteresis collapses under an effect compartment, as fitted for d-tubocurarine [1].
References
[1]
Sheiner LB, Stanski DR, Vozeh S, Miller RD, Ham J. Simultaneous modeling of pharmacokinetics and pharmacodynamics: Application to d-tubocurarine. Clinical Pharmacology & Therapeutics 1979;25:358–71. https://doi.org/10.1002/cpt1979253358.