Pharmacodynamics

Exposure-Response

“What the drug does to the body”

Table 1: Pharmacodynamic symbols

Symbol	Description
E	Effect
I	Inhibition
EC50	Concentration for half of maximum effect
IC50	Concentration for half of maximum inhibition
Emax	Theoretical max effect
Imax	Theoretical max inhibition

Drug effect models

\[ \mathrm{E} = \frac{ \mathrm{E_max} \times \C^\gamma }{ \C^\gamma + \mathrm{EC}^\gamma_{50} } \]

\[ \mathrm{E} = \mathrm{E_0} - \mathrm{slope} \times t \]

(1-compartment)