Pathology Primers

Each primer provides a concise, high-level summary of a disease relevant to pharmacometricians, focusing on biomarkers, drug regimens, and modeling approaches.

Typical structure for disease “XYZ”:

1. What is XYZ?

• Disease definition & pathophysiology
• Commonly used Pharmacodynamic (PD) Models (e.g., disease progression models, target engagement)

2. Patient characteristics

• Typical patient population
• Risk factors & disease progression indicators

3. Diagnosis & biomarkers

• Key Clinical Biomarkers (e.g., lab values, thresholds, imaging)
• Disease Severity Classification (if applicable, e.g., staging systems)

4. How can XYZ be treated?

• Treatment aim (PD-targets)
• Common Drug Classes & Regimens
  • Mechanism of Action (MoA)
  • First-line vs. second-line treatments
  • Dose Adjustments (e.g., renal/liver impairment, pediatrics)
• Commonly used PK-models